Synthesis, Spectroscopic Characterization and Pharmacological Evaluation of Schiff Base molecular Adducts of Copper metal

A series of copper complexes were prepared from N4 – substituted Schiff base ligands having structure [Cu (L)2] Cl2 ; where L= p-methoxy benzylidene ethylene diammine, p-nitro benzylidene ethylene diammine, pchloro acetophenone ethylene diammine, p-methoxy acetophenone ethylene diammine, p-nitro acetophenone ethylene diammine. All copper complexes were characterized by various physicochemical techniques like melting point, TLC, elemental analysis,IR,H1-NMR,LCMS,UV-Visible spectra. The magnetic moments and electronic spectral studies suggested distorted octahedral geometry for all the complexes. The monoanionic ethylene diammine ligands act in a bi dentated mode, binding through azomethine nitrogen atoms.. The synthesized compounds were screened for their in vitro antibacterial activity using Disc Diffusion method against two strains of gram negative and gram positive bacteria. Tetracycline antibiotic was used as positive control in this test. All the compounds showed significant antibacterial activity in the range of 1-10 mg/ml. Antioxidant activity of the all copper complexes was screened using the DPPH scavenging assay. In this activity ascorbic acid was used as a positive control .All complexes exhibited potent antioxidant activity in the range 50-75%. These compounds would be evaluated further for their possible DNA binding, cleavage, antifungal and anti-diabetic activities.